Tranexamic Acid:
Adult IV:
0.5-2 g; 20-25 mg/kg max 4x/d (ceiling effect)
Adult Continuous Infusion:
1-2 mg/kg/hr
Pediatric IV:
10 mg/kg followed by 1–5 mg/kg/hr
Pediatric Continuous Infusion:
1–5 mg/kg/hr
Renal Impairment Dose Adjustment: YES—
- Cr > 1.3 mg/dL 10 mg/kg max. 2x/day
- Cr > 5.5 mg/dL 5 mg/kg max. 1x/day