• Rising lactate
  • Worsening metabolic acidosis
  • Oliguria
  • MAP < gestational age
  • Diastolic Blood Pressure < 25 mmHg
Consider:
  • Echocardiography
  • Sedation or neuromuscular blockade
  • Prostaglandin E1 for RV dysfunction to allow right to left flow through PDA
  • Fluid bolus for hypotension and underfilled LV
  • Sodium bicarbonate for low pH with unimpaired ventilation
  • iCa>1.2, normal magnesium and potassium levels
  • Low dose dopamine and epinephrine, or milrinone for biventricular cardiac dysfunction
  • Low dose vasopressin for catecholamine sparking effect if tachycardic
  • Avoid iNO with LV dysfunction
  • Esmolol for RVOT obstruction

Is there any improvement?