Fibrinogen:

Target:

Active, clinically relevant bleeding: Fibrinogen > 150 mg/dl
No bleeding: Fibrinogen > 100 mg/dl

Adult Dose:

For fibrinogen levels < 1.5 g/L with active bleeding.

Standard Dosing: ~ 50 mg/kg (2- 4 g) adjusted based on fibrinogen levels
Calculated Dosing: desired increase (g/L) x 0.04*kg of bodyweight

Pediatric Dose:

50 mg/kg

ECMO:

After administration watch out for signs of clotting!