Are there any relative contraindications?

  • Severe irreversible neurological injury or high-grade intracranial hemorrhage
  • Irreversible multisystem organ failure
  • Prematurity or low birthweight (newborns < 34/40 gestational weeks should be considered on an individual basis; <32/40 is contraindicated)
  • Severe congenital anomalies or conditions such as malignancy with poor survival prospects
  • Contraindications to anticoagulation or severe or uncontrolled systemic bleeding