Bivalirudin:
Adult Starting Dose:
0.15 mg/kg/hr
Pediatric Starting Dose (Continuous):
0.1–0.3 mg/kg/hr
Renal Impairment Dose Adjustment*:
YES—See table for more information.
| |
| Adults |
- 0.1 mg/kg/hr (CrCr 30–60 mL/min)
- 0.07 mg/kg/hr (CrCr 10–29 mL/min)
- 0.02 mg/kg/hr (CrCr < 10 mL/min)
|
| Pediatrics |
- 0.1 mg/kg/hr (CrCr 30–60 mL/min)
- 0.07 mg/kg/hr (CrCr 10–29 mL/min)
- 0.02 mg/kg/hr (CrCr < 10 mL/min)
|
| Neonates |
- 0.1 mg/kg/hr (CrCr 30–60 mL/min)
- 0.07 mg/kg/hr (CrCr 10–29 mL/min)
- 0.02 mg/kg/hr (CrCr < 10 mL/min)
|
| |
| Target range |
aPTT: 60–80 s (ratio 1.5 – 3.0)
|
| Lower targets in VV ECMO possible* |
aPTT: 45–55 s (ratio 1.35–1.65)
|