Argatroban:
Adult Starting Dose:
0.2 mcg/kg/min
Pediatric Starting Dose (Continuous):
0.75 mcg/kg/min, then adjusted by aPTT
Hepatic Impairment Dose Adjustment*:
YES—decrease starting dose to 0.1 mcg/kg/min
| |
| Target range |
aPTT: 1.5–3x compared to baseline
|
| Lower targets in VV ECMO possible* |
aPTT: 45–55s (ratio 1.35–1.65)
|
| Hemoclot target |
0.4–0.6 mcg/mL
|