| Timing | Within one week of a known clinical insult or new or worsening respiratory symptoms. |
| Chest Imaging1 | Bilateral opacities — not fully explained by effusions, lobular/lung collapse, or nodules. |
| Origin of edema |
Respiratory failure is not fully explained by cardiac failure or fluid overload.
Need objective assessment (e.g., echocardiography) to exclude hydrostatic edema if no risk factors are present. |
| Oxygenation2 |
Mild: 200 mmHg < PaO2:FiO2 < 300 mmHg with PEEP or CPAP > 5 cm H2O3 |
Moderate: 100 mmHg < PaO2:FiO2 < 200 mmHg with PEEP > 5 cm H2O |
|
Severe: PaO2:FiO2 < 100 mmHg with PEEP > 5 cm H2O |