| Drug | Log P | Protein Binding (%) | Metabolism / Elimination | Dose Adjustment on ECMO | Dose Range |
|---|
| Alprostadil | 3.2 | 81 | ~70% to 80% by oxidation during a single pass through the lungs | - | Adult: 5–100 ng/kg/min Pediatric: 5–100 ng/kg/min Neonate: 10–200 ng/kg/min |
| Epoprostenol | 2.4 | 90 | Hydrolyzed in blood and enzymatic degradation | - | Adult: 2–80 ng/kg/min Pediatric: 2–80 ng/kg/min Neonate: 2–80 ng/kg/min |
| Sildenafil | 2.7 | 96 | Hepatic | - | Adult: 10 mg IV every 8 hrs Pediatric: 0.125–0.25 mg/kg/dose IV every 8 hrs; Max Dose: 10 mg IV every 8 hrs Neonate: 0.25–0.5 mg/kg IV every 6–8 hrs Neonatal Infusion for Congenital Diaphragmatic Hernia: Loading Dose: 0.4 mg/kg administered over 3 hours followed by continuous IV infusion of 1.6 mg/kg/day |
| Treprostinil | 1.4 | 91 | Hepatic | - | Adult: 1.25–80 ng/kg/min Pediatric: 1.25–80 ng/kg/min Neonatal: 2–60 ng/kg/min |