Atracurium:

Intravenous nondepolarizing neuromuscular blocking agent

ECMO Dose Adjustment:

NONE

Renal Impairment Dose Adjustment:

NONE

CRRT Dose Adjustment:

NONE

Hepatic Impairment Dose Adjustment:

NONE

Adult Starting Dose^:

Adult Emergency Dose: 1 mg/kg IV x 1

Adult Intermittent: 0.4–0.6 mg/kg IV every 30 min

Adult Continuous Infusion: 4–12 mcg/kg/min

Pediatric Starting Dose^:

Pediatric Emergency Dose: 1 mg/kg IV x 1

Pediatric Intermittent: 0.3–0.6 mg/kg IV every 30 min

Pediatric Continuous Infusion: 5–12 mcg/kg/min

Neonatal Starting Dose^:

Neonatal Emergency Dose: 1 mg/kg IV x 1

Neonatal Intermittent: 0.3–0.6 mg/kg IV every 30 min

Neonatal Continuous Infusion: 5–12 mcg/kg/min

^Always use the lowest effect dose to achieve an objective endpoint (e.g., train-of-four, ventilator synchrony) and ensure adequate pain control and deep sedation prior to and during administration of neuromuscular blocking agents.