Phenytoin:
Intravenous antiseizure agent
ECMO Dose Adjustment:
YES—an increased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing.
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing.
CRRT Dose Adjustmen t:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing.
Hepatic Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing.
Adult Dose^:
Loading Dose: 20 mg/kg IV x 1 (maximum 30 mg/kg) status epilepticus
Maintenance Dose: 7 mg/kg/day IV in 2–4 divided doses
Pediatric Dose^:
Loading Dose: 15–20 mg/kg (maximum 1,000 mg) IV x 1 for status epilepticus
Maintenance Dose: 2–4 mg/kg/dose every 12 hours
Neonatal Dose^:
Loading Dose: 20 mg/kg IV x 1 for status epilepticus
Maintenance Dose: 2–4 mg/kg/dose every 12 hours