Lacosamide:
Intravenous antiseizure agent
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients.
CRRT Dose Adjustment:
YES—a decreased dose may be warranted in some patients.
Hepatic Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients.
Adult Dose^:
Loading Dose: 400 mg IV x 1. Maximum dose of 600 mg IV for status epilepticus
Maintenance Dose: 200 mg IV daily in 2 divided doses
Pediatric Dose^:
Loading Dose: 5–10 mg/kg/dose (maximum 400 mg) IV x 1 infused over 15–30 minutes
Maintenance Dose: 5–7 mg/kg/dose IV every 12 hours
Neonatal Dose^:
Loading Dose: 5–10 mg/kg/dose IV x 1 infused over 15–30 minutes
Maintenance Dose: 2.5–5 mg/kg/dose IV every 12 hours