Valproate:
Intravenous antiseizure agent
ECMO Dose adjustment:
NONE
Renal Impairment Dose Adjustment:
NONE
CRRT Dose Adjustment:
NONE.
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose^:
Loading Dose: 40 mg/kg IV x 1 (maximum 3000 mg) for status epilepticus
Maintenance Dose: 15 mg/kg/day IV in 2–3 divided doses
Pediatric Dose^:
U.S. Boxed Warning: Avoid in children <2 years of age due to increased risk of developing fatal hepatotoxicity
Loading Dose: 40 mg/kg IV x 1 (maximum 3000 mg) for status epilepticus
Maintenance Dose: 10-15 mg/kg/day IV in 3–4 divided doses
Neonatal Dose^:
U.S. Boxed Warning: Avoid in children <2 years of age due to increased risk of developing fatal hepatotoxicity