Cefiderocol:
Intravenous fifth-generation cephalosporin
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose^:
2 g IV over 3 hours, every 8 hours
Pediatric Dose:
Pediatric Dose: Infants ≥2 months and children < 34 kg: 60 mg/kg IV over 3 hours, every 8 hours
- Children and adolescents ≥ 34 kg: 2 g IV over 3 hours, every 8 hours; maximum 2 g/dose
Neonatal Dose:
No information. Use an alternative antimicrobial.