Cefepime:

Intravenous fourth-generation cephalosporin

ECMO Dose Adjustment:

NONE. Perform therapeutic drug monitoring when available to guide dosing. Consider prolonged infusion after loading dose

Renal Impairment Dose Adjustment*:

YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing

CRRT Dose Adjustment:

YES—the dose may need to be increased relative to the renal impairment dose. Perform therapeutic drug monitoring when available to guide dosing

Hepatic Impairment Dose Adjustment:

NONE

Adult Dose:

2 g IV every 8 hours, prolonged infusion favored after loading dose

Pediatric Dose¹:

2 months of age and older: 50 mg/kg IV every 8 to 12 hours; maximum 2 g/dose or 4 g/day

Neonatal Dose²:

*Dose adjustment will be dependent on acuity and severity of impairment

¹Meningitis: 50 mg/kg IV every 8 hours (maximum 6 g/day)

²Meningitis: 50 mg/kg/dose IV every 12 hours