Cefazolin:
Intravenous first-generation cephalosporin
ECMO Dose Adjustment:
YES—an increased dose may be warranted in some patients
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
2 g IV every 8 hours
Pediatric Dose:
1 month of age and older: 100 mg/kg/day IV divided into 3 or 4 equal doses, with a maximum 2 g/dose, 6 g/day (12 g/day for bone/joint infections)
Neonatal Dose:
25 mg/kg/dose IV
Postmenstrual Age ≤ 29 weeks:
- Postnatal Age ≤ 28 days: every 12 hours
- Postnatal Age > 28 days: every 8 hours
Postmenstrual Age 30 to 36 weeks:
- Postnatal Age ≤ 14 days: every 12 hours
- Postnatal age > 14 days: every 8 hours
Postmenstrual Age 37 to 44 weeks:
- Postnatal Age ≤ 7 days: every 12 hours
- Postnatal Age > 7 days: every 8 hours
Postmenstrual age ≥ 45 weeks: every 6 hours