Vancomycin:
Intravenous glycopeptide
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring to guide dosing
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose. Perform therapeutic drug monitoring to guide dosing
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
20 mg/kg IV once, followed by 15 mg/kg IV every 8–12 hours, adjust dose based on therapeutic drug monitoring
Pediatric Dose:
10–15 mg/kg/dose IV every 6–8 hours, adjust dose based on therapeutic drug monitoring
Neonatal Dose:
adjust dose based on therapeutic drug monitoring:
- Postmenstrual Age < 29 weeks: 15 mg/kg/dose IV every 24 hours
- Postmenstrual Age 29 to 35 weeks: 15 mg/kg/dose IV every 12 hours
- Postmenstrual Age > 35 weeks: 15 mg/kg/dose IV every 8 hours