Trimethoprim/sulfamethoxazole:

Intravenous sulfonamide

ECMO Dose Adjustment:

NONE

Renal Impairment Dose Adjustment*:

YES—a decreased dose may be warranted in some patients

CRRT Dose Adjustment:

YES—the dose may need to be increased relative to the renal impairment dose

Hepatic Impairment Dose Adjustment:

NONE

Adult Dose:

5 mg trimethoprim/kg (adjusted bodyweight if BMI > 30) IV every 8 hours

Pediatric Dose¹:

5 mg trimethoprim/kg/dose IV every 6-8 hours

Neonatal Dose:

No data, use alternate antimicrobial

*Dose adjustment will be dependent on acuity and severity of impairment

¹Meningitis: ≥ 29 days of age: 10 to 20 mg/kg/day (based on trimethoprim component) IV in divided doses every 6-12 hours