Tobramycin:
Intravenous aminoglycoside
ECMO Dose Adjustment:
YES—consider repeat load if on therapy when cannulated
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring to guide dosing
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose. Perform therapeutic drug monitoring to guide dosing
Adult Dose:
IV: 7 mg/kg/dose every 24 hours. Adjust dose based on therapeutic drug monitoring
Pediatric Dose:
Adjust dose based on therapeutic drug monitoring:
≥ 3 months to < 2 years of age: 9.5 mg/kg/dose IV every 24 hours
2 to < 8 years of age: 8.5 mg/kg/dose IV every 24 hours
8 to < 18 years of age: 7 mg/kg/dose IV every 24 hours
Neonatal Dose:
Adjust dose based on therapeutic drug monitoring:
Gestational Age < 30 weeks:
- Postnatal Age ≤ 14 days: 5 mg/kg/dose IV every 48 hours
- Postnatal Age > 14 days: 5 mg/kg/dose IV every 36 hours
Gestational Age 30 to 34 weeks:
- Postnatal Age ≤ 10 days: 5 mg/kg/dose IV every 36 hours
- Postnatal Age > 11 to 60 days: 5 mg/kg/dose IV every 24 hours
Gestational Age ≥ 35 weeks:
- Postnatal Age ≤ 7 days: 4 mg/kg/dose IV every 24 hours
- Postnatal Age > 8 to 60 days: 5 mg/kg/dose IV every 24 hours