Tigecycline:
Intravenous glycylcycline
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment:
NONE
CRRT Dose Adjustment:
NONE
Hepatic Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
Adult Dose:
Initial 100 mg IV, followed 50 mg IV every 12 hours
Pediatric Dose:
limited data
8 to11 years of age: 1.2 mg/kg/dose (max dose 50 mg) IV every 12 hours. Increased dosing may be warranted in some patients
12 to 17 years of age: 50 mg IV every 12 hours
Neonatal Dose:
Not enough data for dosing recommendation
*Dose adjustment will be dependent on acuity and severity of impairment