Polymyxin B:

Intravenous polymyxin

ECMO Dose Adjustment:

NONE

Renal Impairment Dose Adjustment:

NONE

CRRT Dose Adjustment:

NONE

Hepatic Impairment Dose Adjustment:

NONE

Adult Dose:

Initial 25,000 units/kg IV, followed by 15,000 units/kg IV every 12 hours

Pediatric Dose:

Initial 25,000 units/kg/dose IV, followed by 12,500 units/kg/dose IV every 12 hours

Neonatal Dose:

Limited data: 12,500 units/kg/dose to 20,000 units/kg/dose IV every 12 hours