Oxacillin:

Intravenous penicillin

ECMO Dose Adjustment:

YES—In the absence of published data, dose at the higher end of the normal dosing range due to potential for sequestration based on drug characteristics. Monitor for clinical efficacy and toxicity

Renal Impairment Dose Adjustment:

NONE

CRRT Dose Adjustment:

NONE

Hepatic Impairment Dose Adjustment:

NONE

Adult Dose:

2 g IV every 4 hours

Pediatric Dose:

100–200 mg/kg/day IV divided every 4-6 hours; maximum 2 g/dose,12 g/day

Neonatal Dose¹:

25 mg/kg/dose IV

Gestational Age ≤ 34 weeks:

Postnatal Age ≤ 7 days: every 12 hours
Postnatal Age 8 to 28 days: every 8 hours

Gestational Age > 34 weeks:

Postnatal Age ≤ 7 days: every 8 hours
Postnatal Age 8 to 28 days: every 6 hours

¹Meningitis: 50 mg/kg/dose IV but safety and efficacy data for dosing of neonates with CNS infection are lacking