Metronidazole:
Intravenous antimicrobial
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
NONE
Hepatic Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
Adult Dose:
500 mg IV every 8 hours
Pediatric Dose:
10 mg/kg/dose (maximum dose: 500 mg) IV every 8 hours
Neonatal Dose:
Postmenstrual Age < 34 weeks: Initial 15 mg/kg IV, followed by 7.5 mg/kg/dose IV every 12 hours
Postmenstrual Age 34 to 40 weeks: Initial 15 mg/kg IV, followed by 7.5 mg/kg/dose IV every 8 hours
Postmenstrual Age > 40 weeks: Initial 15 mg/kg IV, followed by 10 mg/kg/dose IV every 8 hours