Meropenem:
Intravenous carbapenem
ECMO Dose Adjustment:
NONE. Perform therapeutic drug monitoring when available to guide dosing. Consider prolonged infusion after loading dose
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose. Perform therapeutic drug monitoring when available to guide dosing
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
2 g IV every 8 hours, prolonged infusion favored after loading dose
Pediatric Dose 2:
20 mg/kg IV every 8 hours, maximum 1 g/dose, 3 g/day
Neonatal Dose 1:
Gestational Age < 32 weeks:
- Postnatal Age < 14 days: 20 mg/kg IV every 12 hours
- Postnatal Age ≥ 14 days: 20 mg/kg IV every 8 hours
Gestational Age ≥ 32 weeks:
- Postnatal Age < 14 days: 20 mg/kg IV every 8 hours
- Postnatal Age ≥ 14 days: 30 mg/kg IV every 8 hours