Imipenem/cilastatin/relebactam:
Intravenous carbapenem
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
1.25 g IV every 6 hours
Pediatric Dose:
< 3 months of age and ≥2 kg: 37.5 mg/kg (15 mg/kg imipenem, 15 mg/kg cilastatin, 7.5 mg/kg relebactam) IV over 30 minutes every 8 h
≥ 3 months of age: 37.5 mg/kg (15 mg/kg imipenem, 15 mg/kg cilastatin, 7.5 mg/kg relebactam) IV over 30 minutes every 6 hrs, maximum 1.25 g (500 mg imipenem, 500 mg cilastatin, 250 mg relebactam)
Neonatal Dose:
No information. Use alternative antimicrobial