Gentamicin:
Intravenous aminoglycoside
ECMO Dose Adjustment:
YES—consider repeat load if on therapy when cannulated
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring to guide dosing
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose. Perform therapeutic drug monitoring to guide dosing
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
7 mg/kg IV every 24 hours, adjust dose based on therapeutic drug monitoring
Pediatric Dose:
adjust dose based on therapeutic drug monitoring
- ≥3 months to <2 years of age: 9.5 mg/kg/dose IV every 24 hours
- 2 to <8 years of age: 8.5 mg/kg/dose IV every 24 hours
- 8 to <18 years of age: 7 mg/kg/dose IV every 24 hours
Neonatal Dose:
adjust dose based on therapeutic drug monitoring:
Gestational Age < 30 weeks:
- Postnatal Age ≤ 14 days: 5 mg/kg/dose IV every 48 hours
- Postnatal Age > 14 days: 5 mg/kg/dose IV every 36 hours
Gestational Age 30 to 34 weeks:
- Postnatal Age ≤ 10 days: 5 mg/kg/dose IV every 36 hours
- Postnatal Age > 11 to 60 days: 5 mg/kg/dose IV every 24 hours
Gestational Age ≥ 35 weeks:
- Postnatal age ≤ 7 days: 4 mg/kg/dose IV every 24 hours
- Postnatal age > 8 to 60 days: 5 mg/kg/dose IV every 24 hours