Doxycycline:

Intravenous tetracycline derivative

ECMO Dose Adjustment:

NONE. Consider repeat load if on therapy when cannulated

Renal Impairment Dose Adjustment:

NONE

CRRT Dose Adjustment:

NONE

Hepatic Impairment Dose Adjustment:

NONE

Adult Dose:

200 mg IV x1, followed by 100 mg IV every 12 hours

Pediatric Dose:

2.2 mg/kg/dose (max dose 100 mg) IV every 12 hours

Neonatal Dose:

Limited data. Anthrax: 2.2 mg/kg/dose IV every 12 hours