Ampicillin:
Intravenous penicillin
ECMO Dose Adjustment:
YES—Dose at the higher end of the normal dosing range due to potential for sequestration
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
2 g IV every 4 hours
Pediatric Dose1:
50–200 mg/kg/day IV divided every 6 hours; maximum 2 g/dose or 8 g/day
Neonatal Dose2:
Gestational Age ≤ 34 weeks:
Gestational Age > 34 weeks:
*Dose adjustment will be dependent on acuity and severity of impairment
1Meningitis: 300-400 mg/kg/day IV divided every 4 hours, maximum 12 g/day
2Meningitis: Postnatal Age ≤ 7 days: 100 mg/kg/dose IV every 8 hours; Postnatal Age > 7 days: 75 mg/kg/dose IV every 6 hours