Cefuroxime:
Intravenous second-generation cephalosporin
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
1.5 g IV every 8 hours
Pediatric Dose 1:
≥ 3 months of age: 100 to 150 mg/kg/day IV divided every 6 to 8 hours, maximum 2 g/dose, 6 g/day
Neonatal Dose:
Gestational Age < 32 weeks:
- Postnatal Age < 7 days: 50 mg/kg/dose IV every 12 hours
- Postnatal Age ≥ 7 days: 50 mg/kg/dose IV every 8 hours
Gestational Age ≥ 32 weeks:
- Postnatal Age ≤ 7 days: 50 mg/kg/dose IV every 12 hours
- Postnatal Age > 7 days: 50 mg/kg/dose IV every 8 hours