Ceftriaxone:
Intravenous third-generation cephalosporin
ECMO Dose Adjustment:
YES—in the absence of published data, dose at the higher end of the normal dosing range due to potential for sequestration based on drug characteristics. Monitor for clinical efficacy and toxicity
Renal Impairment Dose Adjustment:
NONE
CRRT Dose Adjustment:
NONE
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
2 g IV every 12 hours
Pediatric Dose 1:
50-75 mg/kg IV once daily (or in equally divided doses twice daily); maximum dose 1 g/day
Neonatal Dose 2:
50 mg/kg IV every 24 hours
1Meningitis: 4 g/day
2Meningitis: 100 mg/kg IV loading dose, then 80 mg/kg IV every 24 hours. Use cautiously in neonates with hyperbilirubinemia, especially those born prematurely due to risk of kernicterus