Ceftolozane/tazobactam:
Intravenous fifth-generation cephalosporin
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
3 g IV every 8 hours
Pediatric Dose:
30 mg/kg (20 mg/kg ceftolozane, 10 mg/kg tazobactam) IV over 1 hour up to 60 mg/kg (40 mg/kg ceftolozane, 20 mg/kg tazobactam) IV over 3 hours every 8 hours, maximum 3 g/dose (2 g ceftolozane, 1 g tazobactam)
Neonatal Dose:
30 mg/kg (20 mg/kg ceftolozane, 10 mg/kg tazobactam) IV over 1 hour every 8 hours