Ceftobiprole:
Intravenous fifth-generation cephalosporin
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES— decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES— dose may need to be increased relative to renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
667 mg IV over 2 hours every 6 hours on days 1 to 8, then every 8 hours from day 9
Pediatric Dose:
3 months to < 12 years of age: 20 mg/kg IV infusion over 2 hours every 8 hours; maximum 667 mg/dose
12 years to < 18 years of age: 13.3 mg/kg IV infusion over 2 hours every 8 hours; maximum 667 mg/dose
Neonatal Dose:
No information, use alternative antimicrobial