Ceftazidime/avibactam:
Intravenous third-generation cephalosporin
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
2.5 g IV over 3 hours every 8 hours
Pediatric Dose:
<3 months of age: 37.5 mg/kg (ceftazidime 30 mg/kg and avibactam 7.5 mg/kg) IV over 2 hours every 8 hours
3 to 6 months of age: 50 mg/kg (ceftazidime 40 mg/kg and avibactam 10 mg/kg) IV over 2 hours every 8 hours
6 months to 18 years of age: 62.5 mg/kg (ceftazidime 50 mg/kg and avibactam 12.5 mg/kg) IV over 2 hours every 8 hours; maximum 2.5 g/dose (ceftazidime 2 g and avibactam 0.5 g) (6 g/day ceftazidime for >6 months of age)
Neonatal Dose:
Gestational Age ≥ 31 weeks: 25 mg/kg (ceftazidime 20 mg/kg and avibactam 5 mg/kg) IV over 2 hours, every 8 hours