Ceftazidime:
Intravenous third-generation cephalosporin
ECMO Dose Adjustment:
NONE
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
2 g IV every 8 hours
Pediatric Dose 1:
≥ 29 days: 100-150 mg/kg/day IV divided every 8 hours; maximum 2 g/dose or 6 g/day
Neonatal Dose 2:
30 mg/kg/dose IV
Postmenstrual Age ≤ 29 weeks:
Postmenstrual age 30 to 36 weeks:
Postmenstrual Age 37 to 44 weeks:
Postmenstrual Age ≥ 45 weeks: every 8 hours
*Dose adjustment will be dependent on acuity and severity of impairment
1Meningitis: 150 mg/kg/day IV divided every 8 hours
2Meningitis: 0 to 7 days of age: 100-150 mg/kg/day IV divided every 8 to 12 hours; 8 to 28 days of age: 150 mg/kg/day IV divided every 8 hours