Ceftaroline:
Intravenous fifth-generation cephalosporin
ECMO Dose Adjustment:
YES—dose at the higher end of the normal dosing range due to potential for sequestration
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to the renal impairment dose. Perform therapeutic drug monitoring when available to guide dosing
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
600 mg IV every 8 hours
Pediatric Dose:
- 2 months to < 2 years: 8 mg/kg/dose IV every 8 hours
- 2 years or older ≤ 33 kg: 12 mg/kg/dose IV every 8 hours
- 2 years or older > 33 kg: 400 mg IV every 8 hours, or 600 mg IV every 12 hours, maximum 600 mg/dose or 1.8 g/day
Neonatal Dose:
≥ 34 weeks Gestational Age and 12 days to < 2 months or older: 6 mg/kg/dose IV every 8 hours