Amikacin:
Intravenous aminoglycoside
ECMO Dose Adjustment:
YES—consider a repeat load if the patient is on therapy when cannulated.
Renal Impairment Dose Adjustment*:
YES—a decreased dose may be warranted in some patients. Perform therapeutic drug monitoring when available to guide dosing
CRRT Dose Adjustment:
YES—the dose may need to be increased relative to renal impairment dose. Perform therapeutic drug monitoring when available to guide dosing.
Hepatic Impairment Dose Adjustment:
NONE
Adult Dose:
20 mg/kg (adjusted bodyweight) IV every 24 hours, adjust dose based on therapeutic drug monitoring
Pediatric Dose:
15–30 mg/kg/dose IV every 24 hours. Adjust dose based on therapeutic drug monitoring.
Neonatal Dose:
Adjust dose based on therapeutic drug monitoring:
Gestational Age <30 weeks:
- Postnatal Age ≤ 14 days: 15 mg/kg/dose IV every 48 hours
- Postnatal Age > 14 days: 15 mg/kg/dose IV every 36 hours
Gestational Age 30 to 34 weeks:
- Postnatal Age ≤ 10 days: 15 mg/kg/dose IV every 36 hours
- Postnatal Age > 11 to 60 days: 15 mg/kg/dose IV every 24 hours
Gestational Age ≥ 35 weeks:
- Postnatal Age ≤ 7 days: 15 mg/kg/dose every IV 24 hours
- Postnatal Age > 8 to 60 days: 18 mg/kg/dose IV every 24 hours